Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons
نویسندگان
چکیده
منابع مشابه
Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil.
The neuroprotective effects of MK-801, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, were evaluated in models of cerebral ischemia using Mongolian gerbils. Bilateral occlusion of the carotid arteries for a period of 5 min resulted in a consistent pattern of degeneration of hippocampal CA1 and CA2 pyramidal neurons, which was quantified using an image analyzer. Systemic a...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1991
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1991.62